• gopyaḥ — the young gopīs
  The gopīs of Vraja — the topmost devotees in Gauḍīya theology, the embodiments of mahābhāva, Rādhā's own pārṣadīs. Even at the moment the Mathurā citizens are speaking, the gopīs are not in the arena; the verse is the city remembering them with mingled wonder and pity.
• tāpān — distress
  Tāpa-trayam in Vedānta — three sufferings (self, others, gods). The verse claims the gopīs' threefold tāpa is overcome simply by paśyantyaḥ — by seeing. Gauḍīya note: bhakti's results outpace any other path's by orders of magnitude; what jñāna takes lifetimes to remove, darśana of Kṛṣṇa removes in one glance.
• hasita-prekṣaṇam — with smiling glances
  The hasita — smile — is one of Kṛṣṇa's catalogued mādhurya-features. Rūpa Gosvāmī's Bhakti-rasāmṛta-sindhu places Kṛṣṇa's mandahāsa among the daśa-vidha lakṣaṇas of His form. The whole mood of vipralambha-bhakti turns on this smile. A contiguous-token join of synonyms 'hasita' and 'prekṣaṇam'.
• aśramam — free from fatigue
  Kṛṣṇa's face is ever-fresh — a-śrama, no tiredness. The Bhāgavata aesthetic: Bhagavān's form never wilts, never ages, never wearies; this nityaṁ-nava beauty is what holds the gopīs' attention eternally (cf. Brahma-saṁhitā 5.33: advaitam acyutam anādim ananta-rūpam, nava-nava-vatāram).

The gopīs' three-fold tāpa — adhyātmika, adhibhautika, adhidaivika — is dissolved not by yoga or knowledge but by one sight of Kṛṣṇa's smiling face. His mukha is the medicine; their darśana is the dose. This is the simplest soteriology in the Bhāgavatam: see Him, and the threefold suffering ends.