Caitanya-caritāmṛta 3.61
bhaktira virodhī karma-dharma vā adharma tāhāra ’kalmaṣa’ nāma, sei mahā-tamaḥ
[bhaktira virodhee karma-dharma vaa adharma taahaara ’kalmasha’ naama, sei mahaa-tamah]
Blended reading (Sanskrit + English inline)
bhaktira virodhī karma-dharma vā adharma tāhāra ’kalmaṣa’ nāma, sei mahā-tamaḥ
The greatest ignorance consists of activities, whether religious or irreligious, that are opposed to devotional service. They are to be known as sins [kalmaṣa].
My note
Source: vedabase.io